Human Animal Hybrid Chimeras Mean One Thing: Catgirls

…and also other assorted kemonomimi!

     A recent peer-reviewed article explored creating human-mammalian hybrid chimera, such that the resulting living being would have select traits of each species:

Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies blastocyst complementation might allow human organ generation in animals whose organ size, anatomy, and physiology are closer to humans. To date, however, whether human PSCs (hPSCs) can contribute to chimera formation in non-rodent species remains unknown. We systematically evaluate the chimeric competency of several types of hPSCs using a more diversified clade of mammals, the ungulates. We find that naïve hPSCs robustly engraft in both pig and cattle pre-implantation blastocysts but show limited contribution to post-implantation pig embryos. Instead, an intermediate hPSC type exhibits higher degree of chimerism and is able to generate differentiated progenies in post-implantation pig embryos.

     So, we can loot forward to kemonomimi with aspects of cows and piggies.

     This is solid and concrete science which can—and will—lead to development, of other mammalian kemonomimi, including, of course, 猫耳 (AKA Catgirls). Finally, Federal funding well spent!

     Some people question the wisdom of genetic engineering, particularly when it involves creating life from nothingness or creating human-animal hybrids. The counterpoint, however, is far more convincing:

     The full article can be read below:

Interspecies Chimerism With Mammalian Pluripotent Stem Cells by ThePoliticalHat on Scribd

Tweet