Puberty blockers are being increasingly pushed and used on children as a matter of course under the idea that puberty will just be paused for a while, and that the children can then decide to transition via cross-sex hormones if their transgenderism persists. That they can not become the opposite sex is science. But the idea that all that is happening is that puberty is “put on pause” and that they can just start it up again without any consequences… is also a lie, and a potentially far more dangerous one because it is more believable to those who don’t know better. Thankfully there are those who highlight the lies and provide factual information to the contrary.
It turns out that puberty blockers don’t allow the body to conform to a transgender child’s transgender brain, but actually change the brain chemistry so it becomes “transgender”, or at least makes the child more likely to persist in their beliefs.
How does “pausing” puberty by GnRH analogues effect the development of the brain?
Sex-hormones at puberty are now thought to cause a second wave of structural reorganisation, as well as their activational effects. https://t.co/qPVDyJN04B
— Sam Stagg (@SammySammyStagg) November 20, 2021
Independent of gonadal steroids, there is a progressive decrease in the brains sensitivity to testosterone that continues into adulthood. pic.twitter.com/bgZobs6Hxv
— Sam Stagg (@SammySammyStagg) November 20, 2021
GnRH analogues will stop the age appropriate increase in sex hormones, but they will not stop this critical period of the brains sensitivity.
— Sam Stagg (@SammySammyStagg) November 20, 2021
The decrease in the brains sensitivity to testosterone has been shown to effect sex-typical cognitive abilities, as measured by cognitive assessment in individuals with different pubertal timing. https://t.co/3hMUFCC8ER
— Sam Stagg (@SammySammyStagg) November 20, 2021
Puberty is a critical period for many neural changes, such as synaptic pruning, dendritic arborisation and myelination. These can be modulated by the brains sensitivity to sex hormones. https://t.co/SETXaP83vK
— Sam Stagg (@SammySammyStagg) November 20, 2021
Many theories of transgenderism suggest that their brains are mis-matched from their natal sex due to the different timings of sex hormone synthesis and brain development in utero.
— Sam Stagg (@SammySammyStagg) November 20, 2021
However, puberty allows for a structural reorganisation of the brain (contributing to higher sex-typed behaviour) so normal “gender-typical” development can occur.
— Sam Stagg (@SammySammyStagg) November 20, 2021
Since the majority of gender dysphoric children desist from the on-set of puberty, it’s tempting to suggest that pubertal reorganisation of the brain “corrects” their development. https://t.co/UJwz7eowRm
— Sam Stagg (@SammySammyStagg) November 20, 2021
The vast majority of gender dysphoric children on GnRH analogues go onto persist with dysphoric feelings post-puberty. https://t.co/7FhZHx6FAH
— Sam Stagg (@SammySammyStagg) November 20, 2021
In fact, 43 out of 44 gender dysphoric kids who take GnRH analogues go onto gender affirming treatments. https://t.co/8cdzkQY8jR
— Sam Stagg (@SammySammyStagg) November 20, 2021
It seems that “pausing” puberty and missing the sensitive period of brain sensitivity to testosterone may act as a gas pedal and accelerate gender dysphoria persistence by not allowing the natural reorganisation of sex typical brain changes.
— Sam Stagg (@SammySammyStagg) November 20, 2021
For an overview of how sex hormones and puberty influence mammalian brain development, check my previous thread full of citations: https://t.co/CJurIdpvVB
— Sam Stagg (@SammySammyStagg) November 20, 2021
For more reviews on the reorganisational effects of hormones and brain development, check these: https://t.co/O6fv4wZpU2
— Sam Stagg (@SammySammyStagg) November 20, 2021
— Sam Stagg (@SammySammyStagg) November 20, 2021
That other thread mentioned above can be read below:
How do puberty and sex hormones influence the development and plasticity of the mammalian brain?
To answer this, we need to first understand the process of the gonadotrophin-releasing hormone (GnRH) neuronal network in regulating sex hormone synthesis.
— Sam Stagg (@SammySammyStagg) October 17, 2021
GnRH neurons in the hypothalamus send their axons to the median eminence and release GnRH into the portal system. GnRH then binds to gonadotroph cells in the anterior pituitary to release two gonadotropins (luteinizing and follicle-stimulating hormone; LH & FSH, respectively). pic.twitter.com/M3SK73ntYh
— Sam Stagg (@SammySammyStagg) October 17, 2021
LH and FSH then act on the gonads to produce androgens in males (testosterone & dihydrotestosterone), and estrogens in females (estradiol and progesterone).
This system largely lays dormant until puberty (tanner stage 2). https://t.co/GMyotRFYJK
— Sam Stagg (@SammySammyStagg) October 17, 2021
Androgen and estrogens bind to cytoplasmic nuclear receptors which then dimerize and bind to hormone-response-elements (HREs) within DNA promoters and recruit either co-activators or repressors to regulate gene activity.
Both hormones are vital in adolescent brain development. pic.twitter.com/kJQqEk2jsl
— Sam Stagg (@SammySammyStagg) October 17, 2021
Androgen and estrogens bind to cytoplasmic nuclear receptors which then dimerize and bind to hormone-response-elements (HREs) within DNA promoters and recruit either co-activators or repressors to regulate gene activity.
Both hormones are vital in adolescent brain development. pic.twitter.com/kJQqEk2jsl
— Sam Stagg (@SammySammyStagg) October 17, 2021
In a longitudinal study, puberty significantly related to sub-cortical grey matter changes in both sexes in all regions analyzed. The amygdala + hippocampus increased, whereas the striatum, globus pallidus & nucleus accumbens decreasedhttps://t.co/V0lsx4skON
— Sam Stagg (@SammySammyStagg) October 17, 2021
A similar study also found that sex hormones at tanner stage 2 were associated with increased amygdala volume https://t.co/67qdVwDrPQ
— Sam Stagg (@SammySammyStagg) October 17, 2021
LH, FSH, testosterone, and estrogens measurements were taken in 9-year-old twins and re-examined at 12 years old with MRI scans to reveal changes in gray matter density in frontal and parietal regions. https://t.co/bnVIWhtOCB
— Sam Stagg (@SammySammyStagg) October 17, 2021
Testosterone also contributes to the structural co-variance between the amygdala and medial prefrontal cortex (mPFC). Behavioral assessment of aggression also correlated with this co-variance. https://t.co/b7RyCZA6id
— Sam Stagg (@SammySammyStagg) October 17, 2021
Neural-plasticity mechanisms may also be under the control of sex hormones.
Adolescence is a sensitive period for brain plasticity, in which it can be decreased in some regions, or increased in others. This process can be highly sex-specific.
— Sam Stagg (@SammySammyStagg) October 17, 2021
It's known that estrogens can increase the number of dendritic spines in CA1 hippocampal pyramidal neurons (in rodents; although the same is thought to occur in humans). https://t.co/OMwGSgg1XM
— Sam Stagg (@SammySammyStagg) October 17, 2021
Puberty-associated increases in gonadal steroids are essential for the sex-specific increases in dendritic spine formation, and thus increased brain plasticity. Although, this process declines as we get older.
— Sam Stagg (@SammySammyStagg) October 17, 2021
Neurons also increase in myelination as we get older, which improves the speed and conductance of electrical signals (action potentials). This process is actually correlated with decreased plasticity, as our neural circuits become more stable. pic.twitter.com/mI7Os7pr92
— Sam Stagg (@SammySammyStagg) October 17, 2021
It has been shown that ovariectomized rats (less estrogen) had a higher degree of myleination. Therefore, higher production of estrogen at puberty may decrease (or prolong) myelination at puberty and increase brain plasticity. https://t.co/RlANZnqhTM
— Sam Stagg (@SammySammyStagg) October 17, 2021
Overall, sex hormones at puberty (via GnRH activation) have a variety of roles in structural, behavioural, and plastic mechanisms within the mammalian brain. Many of these processes are dynamic and can be sex-specific.
— Sam Stagg (@SammySammyStagg) October 17, 2021
Lastly, sex hormones have organizational and activational effects on the brain. The organizational effect is created in utero and awaits the activational stage in which a surge of these hormones is needed to affect adolescent brain maturation.
— Sam Stagg (@SammySammyStagg) October 17, 2021
Despite this, hospitals are still pushing these dangerous drugs that haven’t been approved by the FDA for blocking the normal development of puberty.
Seattle Children’s Hospital calls puberty blockers a pause button.
This plays a nice little trick on the mind, implying no harm done, but they are not a pause button. They are a stop button.
Virtually 100% of kids go on to the opposite-sex hormones, causing sterility. pic.twitter.com/DgZKuYjrZ7
— 🅑🅘🅛🅛🅑🅞🅐🅡🅓 🅒🅗🅡🅘🅢 (@BillboardChris) January 4, 2022
“Blocking puberty can make your bones weaker.”
A girl in Sweden just suffered spinal fractures.
“Permanent damage to fertility is a concern for people who stay on puberty blockers and then take cross-sex hormones.”
Girls are getting their uterus removed due to atrophy. pic.twitter.com/GSgkN7ruzn
— 🅑🅘🅛🅛🅑🅞🅐🅡🅓 🅒🅗🅡🅘🅢 (@BillboardChris) January 4, 2022
These drugs have never been approved by the FDA for blocking healthy puberty.
They are approved for prostate cancer, endometriosis, and are also used to chemically castrate pedophiles. https://t.co/n9iQr4QvrP
Children’s hospitals experiment on kids with them for years. pic.twitter.com/PWRRUiq0HO
— 🅑🅘🅛🅛🅑🅞🅐🅡🅓 🅒🅗🅡🅘🅢 (@BillboardChris) January 4, 2022
It continues to stun me how casually all of these hospitals and gender clinics will permanently harm a child’s body for life.
Bone loss, infertility, amputations, shortened life span, cognitive declines, depression, anorgasmia, etc., and we celebrate it.
Let kids grow up!
— 🅑🅘🅛🅛🅑🅞🅐🅡🅓 🅒🅗🅡🅘🅢 (@BillboardChris) January 4, 2022
Pingback: In The Mailbox: 01.18.22 : The Other McCain